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Troy L. Ott
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Troy L. Ott

  • Associate Professor of Reproductive Physiology
321 Agricultural Sciences and Industries Building
University Park , PA 16802
E-mail:

Office Phone: (814) 441-2657

Web Sites

Education

  1. Research Scientist, 1992-98, Center for Animal Biotechnology, Texas A&M University
  2. Ph.D., 1992, University of Florida - Reproductive Physiology
  3. M.S., 1988, Auburn University - Reproductive Physiology
  4. B.S., 1984, The Pennsylvania State University - Animal Production

Professional Experience

  • 2006-Present: Associate Professor of Reproductive Physiology, Dairy and Animal Science Department, Department of Veterinary and Biomedical Sciences, Penn State University
  • (2004-2006); Associate Professor, Department of Animal and Veterinary Sciences, University of Idaho, Moscow, Idaho.
  • Affiliate Faculty (7/04 – 06); Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle.
  • Affiliate Faculty (9/04- 06): Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow.
  • Assistant Professor (6/98-6/04): Department of Animal and Veterinary Sciences, University of Idaho, Moscow, Idaho.
  • Research Scientist (11/95-5/98): Center for Animal Biotechnology, Institute of Biosciences and Technology, Texas A&M University.
  • Assistant Research Scientist (5/92-11/95): Center for Animal Biotechnology, Institute of Biosciences and Technology, Texas A&M University.

Research

Physiology of Reproduction/Reproductive Immunology

Early embryonic mortality in livestock occurs at a rate of 30-40 percent in cattle, sheep and swine, and exceeds 50 percent in horses. It is also a significant problem in human reproductive medicine. The primary focus of research in the lab is the molecular mechanisms regulating fertility and infertility in domestic farm animals. A secondary focus is on regulation of the innate arm of the mucosal immune system of the female reproductive tract. In both cases the lab has basic (mechanistic) research projects and applied (translational) research interests. Relative to the former, research is ongoing to characterize the function of members of the interferon stimulated gene family in establishment and maintenance of pregnancy in ruminants. Current research is focused on defining mechanisms that mediate secretion by the uterine mucosa. We believe these processes are critical for providing nutritional support to the early embryo. We are approaching this using a host of molecular technologies including yeast 2-hybrid screening, RNA interference, plasmid-mediated protein over-expression and promoter-reporter assays to characterize the expression and function of members of this gene family in the uterus, ovary and peripheral blood immune cells. The second research focus area is regulation of the mucosal immune system in the female reproductive tract. The basic focus of this work is to understand how steroid hormones, principally progesterone, modulate the innate arm of the mucosal immune system in the female reproductive tract. This work has application to alleviating problems associated with disease transmission in livestock and humans.

MX1 Induction and Localization in an ovine glandular epithelial cell line following treatment with interferon tau.

Links

Publications

  • Gifford, C.A., Assiri, A.M., Satterfield, M.C., Spencer, T.E. and Ott, T.L. (2008). Receptor transporting protein-4 (RTP-4), in endometrium, ovary and peripheral blood leukocytes of pregnant and cyclic ewes. Biology of Reproduction 79(3):518-24. PDF
  • Stevenson, J.L., Dalton, J.C., Ott, T.L., Racicot, K.E. and Chebel, R.C. (2007). Correlation between reproductive status and steady-state mRNA levels of the Myxovirus resistance gene, MX2, in peripheral blood leukocytes of dairy heifers. Journal of Animal Science. 85(9):2163-72.
  • Ocón-Grove, O.M, Cooke, F.N.T., Alvarez, I.M., Johnson, S.E., Ott, T.L. and Ealy, A.D. (2007). Ovine Endometrial and Conceptus Expression of Fibroblast Growth Factor (FGF)-2 and FGF Receptors during Early Pregnancy. Domestic Animal Endocrinology. 34(2):135-45.
  • Ferens, W.A., Halver, M., Gustin, K.E., Ott, T.L., Hovde, C.J. (2007) Differential sensitivity of viruses to the antiviral activity of Shiga toxin 1 A subunit. Virus Research 125: 104-108.
  • Goodwin, J.L., Murphy, T. H., Jensen, J., Jacobson, R., Woloshuk, J., Shulaw, W., Ott, T.L., Peterson, R., Busboom, J., Cosner, B., Newman, J., Lemaster, J.W. and M. Pike. (2007). Measurement and description of lambs docked at the distal end of the caudal fold. Journal of Extension 45(4):4FEA7
  • Assiri, A.M. and Ott, T.L. (2007). Cloning and characterizing of the ovine Mx1 gene promoter/enhancer region. Developmental and Comparative Immunology 31(8):847-57. PDF
  • Gifford, C.A., Racicot, K., Clark, D.S., Austin, K.J., Hansen, T.R., Lucy, M.C., Davies, C.J., Ott, T.L. (2007). Regulation of Interferon Stimulated Genes in Peripheral Blood Leukocytes in Pregnant and Bred, Non-pregnant Dairy Cows. Journal of Dairy Science 90(1):274-280. PDF
  • Toyokawa, K., Carling, S.J. and Ott, T.L. (2007). Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1): I. Ovine Mx1 is secreted by endometrial epithelial cells via an unconventional secretory pathway. American Journal of Reproductive Immunology 57: 13-22 PDF
  • Toyokawa, K., Leite, F. and Ott, T.L. (2007). Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1): II. The oMx1 protein is a regulator of secretion in an ovine glandular epithelial cell line. American Journal of Reproductive Immunology 57:23-33. PDF
  • Williams, G.A., Ott, T.L., Michal, J.J., Gaskins, C.T., Wright, R.W. and Jiang, Z. (2007) Development of a novel model for mapping the genetic complexity of cryptorchidism in sheep and initial evidence of association of INSL3 with the defect. Animal Genetics dci:10.1111/j1365-2052.2007.01585.x
  • Garcia, M.D., Michal, J.J., Gaskins, C.T., Reeves, J.J., Ott, T.L., Liu, Y. and Jiang, Z. (2006) Significant associations of the calpastatin gene with fertility and longevity in dairy cattle. Animal Genetics 37:304-305.
  • Hostetler, C.E., Michael, J., Robison, M.R., Ott, T.L. and Kincaid, R.L. (2006). Effect of selenium intake and fetal age on mRNA expression of two selenoproteins in porcine fetal and maternal liver. Journal of Animal Science 84:2382.
  • Hartt, L., Carling, S.J., Joyce, M.M, Johnson, G.A., Vanderwall, D.K. and Ott, T.L. (2005). Temporal and spatial associations of oestrogen receptor alpha and progesterone receptor expression in the endometrium of pregnant and non-pregnant mares. Reproduction, 130: 1-11.
  • Biga, P.R., Peterson, B.C., Schelling, G.T., Hardy, R.W., Cain, K.D., Overturf, K., and Ott, T.L. (2005) Serum somatotropin, insulin-like growth factor-I, and antibody production in rainbow trout (Oncorhynchus mykiss) treated with sustained-release bovine somatotropin (rbST). Aquaculture. Vol 246: 437-445.
  • Jiang. Z., Wu, X.L., Garcia, M.D., Griffin, K.B., Michal, J.J., Zhang, M., Wasem, V.D., Ott, T.L., Gaskins, C.T. and Wright, R.W. Jr. (2004). Comparative Gene-based Anatomy of Different Tissues/Organs in Cattle: Transcriptomes, Expression Similarities and Preferentially Expressed Genes Based on the Expressed Sequence Tags. Genome 47: 1164-1172.
  • Biga, P.R., Cain, K.D., Hardy, R.W., Overturf, K., Schelling, G.T., and Ott, T.L. (2004). The effects of recombinant bovine somatotropin (rbST) on tissue IGF-I, IGF-I receptor, and GH mRNA levels in rainbow trout (Oncorhynchus mykiss). General and Comparative Endocrinology. 135: 324-333.
  • Biga, P.R., Cain, K.D., Hardy, R.W., Schelling, G.T., Overturf, K., and Ott, T.L. (2004). Growth hormone differentially regulates muscle myostatin-1 and -2 and increases circulating cortisol in rainbow trout (Oncorhynchus mykiss). General and Comparative Endocrinology. 138: 32-41.
  • Hicks, B.A., Yankey, S.J., Carnahan, K.G., Joyce, M.M., Assiri, A.M., Sinor, S.J. Kodali, K., Johnson, G.A., Hansen, T.R., Mirando, M.A., Woods, G.L., Vanderwall, D.K. and Ott, T.L. (2003). Expression of the uterine Mx protein in cyclic and pregnant cows, gilts, and mares. Journal of Animal Science 81:1552-1561.
  • Peterson, B.C., Simpson, P.R., Cain, K.D., Hardy, R.H., Schelling, G.T., and Ott, T.L. (2003). Effects of Administration of Somatostatin-14 and Immunoneutralization of Somatostatin on endocrine and Growth Responses in Rainbow Trout (Oncorhynchus mykiss). Journal of Fish Biology 63:1-17.
  • Kubotsu, S.L., Hu, J., Carnahan, K.G., deAvila, J., Ott, T.L. and Mirando, M.A. (2003). The effects of chronic ethanol consumption during early pregnancy on conceptus health and uterine function in pigs. Alcoholism: Clinical and Experimental Research, 27:712-719.
  • Johnson, G.A., Joyce, M.M., Yankey, S.J., Hansen, T.R. and Ott, T.L. (2002). The interferon stimulated genes (ISG) 17 and Mx have different temporal and spatial expression in the ovine uterus suggesting more complex regulation of the Mx gene. Journal of Endocrinology 147(2):R7-R11.
  • Yankey, S.J., Hicks, B.A., Carnahan, K.G., Assiri, A., Sinor, S.J., Kodali, K., Stellflug, J.N. and Ott, T.L. (2001). Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes. Journal of Endocrinology 170, R7-R11.
  • Singh B., Ott, T.L., Bazer, F.W., and de la Concha-Bermejillo, A. (2001). Phenotypic and Ultrastructural Characteristics of Bronchoalveolar Lavage Cells of Lentivirus-Infected Lambs Treated with Recombinant Ovine Interferon-tau. Journal of Interferon and Cytokine Research 21(9):677-686.
  • Ott, T.L. (2000). Interferon-tau: paracrine mediator of conceptus-maternal dialogue in ruminants. Annales, Universitatis Mariae Curie-Sklodowska. Sectio DD, Medicina Veterinaria. Vol. LV/B, pgs 1-5.
  • Juste, R.A., Ott, T.L., Kwang, J., Bazer, F.W. and de la Concha-Bermejillo, A. (2000). Effects of recombinant ovine interferon-J on ovine lentivirus replication and progression of disease. Journal of General Virology 81(2): 525-532.
  • Gray, A.G., Bartol, F.F., Taylor, K.M., Wiley, A.A., Ramsey, W.S., Ott, T.L., Bazer, F.W. and Spencer, T.E. (2000). The ovine uterine gland knock out model: Effects of gland ablation on the estrous cycle. Biology of Reproduction 62:448-456.
  • Kim, H-T, Stoica, G., Bazer, F.W. and Ott, T.L. (2000). Interferon-tau (IFNJ)-induced apoptosis in ovine hepatocytes. Hepatology 31:1275-1284.
  • Chami, O., Megevand, A., Ott, T.L., Bazer, F.W. and O¡¦Neill, C. (1999) Platelet-activating factor may act as an endogenous pulse generator for sheep of luteolytic PGF2alpha release. American Journal of Physiology 276:E783-792.
  • Spencer, T.E., Gray, A., Johnson, G.A., Taylor, K.M., Gertler, A., Gootwine, E., Ott, T.L. and Bazer, F.W. (1999). Effects of Recombinant Ovine Interferon Tau, Placental Lactogen, and Growth Hormone on the Ovine Uterus. Biology of Reproduction 61:1409-1418.
  • Bartol F.F., Wiley A.A., Floyd J.G., Bazer F.W., Ott T.L., Spencer T.E. (1999). Uterine differentiation as a foundation for subsequent fertility. Journal of Reproduction and Fertility; Suppl 54:285-300.
  • Johnson, G.A., Burghardt, R.C., Spencer, T.E., Newton, G.R, Ott, T.L. and Bazer, F.W. (1999). Ovine Osteopontin: II. Osteopontin and alpha-v beta-3 Integrin Expression in the Uterus and Conceptus During the Periimplantation Period. Biology of Reproduction 61: 892-899.
  • Tuo, W., Ott, T.L., Liu, S-H. and Bazer, F.W. (1999). Intrauterine infusion of bacterial lipopolysaccharide (LPS) prior to mating has no adverse effects on fertility, fetal survival and fetal development. Journal of Reproductive Immunology 42:31-39.
  • Ing, N.H. and Ott, T.L. (1999). Estradiol up-regulates estrogen receptor messenger RNA by increasing its stability. Biology of Reproduction 60:134-139.
  • Wu, G., Ott, T.L., Knabe, D.A. and Bazer, F.W. (1999). Amino acid composition of the fetal pig. Journal of Nutrition 129:1031-1038.
  • Spencer, T.E., Gray, C.A., Ott, T.L., Johnson, G.A., Ramsey, W.S., and Bazer, F.W. (1999). Differential effects of intrauterine and subcutaneous administration of recombinant ovine interferon tau (roIFNJ) on endometrial gene expression of cyclic ewes. Biology of Reproduction 61:464-470.
  • Ott, T.L., Yin, J., Wiley, A.A., Kim, H.-T., Gerami-Naini, B., Spencer, T.E., Bartol, F.F., Burghardt, R.C. and Bazer, F.W. (1998). Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries). Biology of Reproduction 59:784-794.
  • Singh, B., Ott, T.L., Bazer, F.W. and De La Concha-Bermejillo, A. (1998). Structural responses of pulmonary intravascular macrophages in lentivirus-infected and/or recombinant ovine interferon-J-treated lambs. The Anatomical Record 251:472-485.
  • Bazer, F.W., Ott, T.L. and Spencer, T.E. (1998). Maternal recognition of pregnancy: Comparative aspects. Trophoblast Research 12:375-386.
  • Spencer, T.E., Ott, T.L. and Bazer, F.W. (1998). Expression of interferon regulatory factors one and two in the ovine endometrium: Effects of pregnancy and ovine interferon tau. Biology of Reproduction 58:1154-1162.
  • Piedrahita, J.A., Moore, K., Oetama, B., Lee, C.-K., Scales, N., Ramsoondar, J., Bazer, F.W., Ott, T.L. (1998). Generation of transgenic porcine chimeras using primordial germ cell (PGC)-derived colonies. Biology of Reproduction 58:1321-1329.
  • Wu, G., Pond, W.G., Flynn, S.P., Ott, T.L. and Bazer, F.W. (1998). Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and endometrium of pigs during early gestation. Journal of Nutrition 128: 2395-2402.
  • Wu, G., Pond, W.G., Ott, T.L. and Bazer, F.W. (1998). Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs. Journal of Nutrition 128:894-902.